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Possess a digenetic lifestyle cycle, involving a motile, extracellular promastigote stage that parasitizes the alimentary tract of the sandfly vector and an immotile amastigote phase that survives and replicates while in the phagolysosomes of mononuclear phagocytes [two,3]. Besides individuals, primary hosts of Leishmaniahairy roots to find out the

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Complicating drug interactions even further, lumacaftor is itself a strong inducer of CYP3A and can therefore limit the efficacy of medicine that are cleared by way of this metabolic pathway. Especially, the efficacy of hormonal contraceptives is impaired and different methods of contraception should be used in order to avoid pregnancy when employi

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